&e1=Glucose 6-phosphate dehydrogenase &e2=6-phosphogluconate dehydrogenase&e3=Epimerase &e4=Isomerase &e5=Transketolase&e6=Transaldolase&e7=Transketolase&e8=Lactonase&e9=&e10=&e11=&c1=&c2=&c3=&c4=&c5=Thiamine-pyrophosphate&c6=&c7=Thiamine-pyrophosphate&c8=&c9=&c10=&c11=&k1=&k2=The decarboxylation of the beta-ketoacid can occur spontaneously, but is faster with the dehydrogenase enzyme.&k3=&k4=Although the substrates and enzymes are different, the chemistry of the isomerase reaction is just like it is for the two isomerases in glycolysis.&k5=The role of TPP in this reaction is similar to its role in pyruvate dehydrogenase complex.  It acts as a two carbon carrier by binding to the keto group and promoting breaking of the C2-C3 bond.&k6=In transketolase and transaldolase reactions, the keto sugar is always the fragment donor and is shortened while the aldose is always the fragment acceptor and is lengthened.&k7=&k8=&k9=&k10=&k11=&
